Yes, Lexus's pattern is definitely weird and results in uneven wear.
Ever since my Jeep days, I've always done a simple clockwise 5-tire rotation. My thinking is that they'll eventually all even out any way, and the benefit from the simplified instruction seems to outweigh the maybe slight advantage of either the Discount Tire or BFG recommended pattern.
What do you guys think?
I think the factory OEM tires are likely not going to last 50k miles, and more likely 30-40k miles. I'm generalizing, but thinking this for a Prem/Prem+, Lux/Lux+.
That being so, if you do a four tire rotation instead of five, and when it's 30-40k miles and time for new tires you decide to use brand X, then you have one remaining OEM tire, your spare, that is brand Y. There are a few advantages in this: 1) You purchase, and pay to install and to balance, four instead of five tires, (saving app. $300-$400). 2) Your rotations in the first 30-40k miles take slightly less labor and time, with a slightly offset by the 5k and 10 mile rotation being no cost to you. 3) You get even wear on four tires, which is questionable if will be noticeable in ride quality (e.g., you're cruising along an interstate highway are you going to notice one tire has 5k or 10k more miles on it than the other three tires?).
The only disadvantage I see in the above, when you're on the 2nd set of tires, is if or when you have to use the spare, say a nail in a tire, damaged sidewall, damaged rim etc., them you're driving on three tires of brand X, and one tire of brand Y (your one remaining OEM tire). This is probably the one situation where you will notice the difference in ride or handling. Even so this may be a temporary situation until you get to a BFG/GY/Firestone/Discount Tire store and get the damaged tire fixed. Or the damaged rim replaced.
I'll be curious to read what others think.